GLUMA® Desensitizer
Gaining victory over pain
For over 20 years, one drop of GLUMA has been sufficient to reduce and prevent hypersensitivity. The results appear quickly and effectively, without mixing, curing or multiple applications. Your patients feel immediate relief.
Every good restoration starts with the GLUMA Desensitizer. Its efficacy has been proven in over 50 million restorations.
Benefits
GLUMA Desensitizer can be used with all common adhesives and restoration materials and in every treatment situation.
- Desensitizes:
Penetrates exposed tubuli up to 200 μm1, forms multiple layers of protein septa which prevent intertubular fluid movements. - Inhibits bacteria:
Provides a hermetic seal that acts as a microbial barrier, inhibiting bacterial growth. - Re-wet:
Resurrects collapsed collagenous fibres, improving the bond strength of many adhesives.
Good to know
Indications
For the reduction of hypersensitivity in exposed cervical areas and on teeth prepared to receive a restoration or a fixed prosthesis.
Doctor / Assistant – Under every restoration
Use GLUMA® Desensitizer below every restoration – direct and indirect – to ensure your patients the comfort they deserve.
- Below crowns
- Bridges
- Inlays and onlays
- Veneers and temporaries
- Margins around temporary crowns
- Below all direct restorations
Dental hygienist – Desensitization
Patients will appreciate the fast, effective and long-term results of a comfortable prophylaxis.
- Tooth neck erosion
- Exposed dentine
- Hypersensitive teeth due to gingiva recession
Applications
Step-by-step application
Science
Schematic representation of effect:
Blue: Intradental sealing induced by GLUMA Desensitizer within dentinal tubuli
SEM of GLUMA-induced septa in dentinal tubuli.¹
SEM magnification of a single Gluma-induced septum in dentinal tube.¹
1 Source: Schweppe J, Hoffmann M, Kastrati A, Utterodt A, Riedel N, Schaub M: Effect of GLUMA Desensitizer on Bond Strength of Etch & Rinse Adhesives. J Dent Res 90 (Spec Issue A): 3172, 2011.
FAQ
For which indications can GLUMA Desensitizer be used?
GLUMA Desensitizer is indicated for the treatment of hypersensitive dentine. They eliminate pain in exposed cervical areas which do not require restoration, and alleviate or prevent dentinal sensitivity after preparing the teeth to receive direct or indirect restorations.
When does GLUMA Desensitizer need to be applied in combination with a dental adhesive?
GLUMA Desensitizer is suitable prior to the placement of direct and indirect restorations. The desensitizer function solely within the dentinal tubuli. Thus, they do not interfere with dental adhesives nor adhesive resin-based luting materials.
In combination with adhesives used in total etch or selective enamel etching technique, GLUMA Desensitizer should be applied after phosphoric acid etching.
In case of self-etch adhesives, GLUMA Desensitizer is to be applied prior to the adhesive.
How long is the application time of GLUMA Desensitizer?
GLUMA Desensitizer should be left on the dentine for 30-60s. Afterwards, it needs to be rinsed off with plenty of water.
Is GLUMA Desensitizer compatible with dental adhesives and resin-based luting cements?
Various studies have confirmed that GLUMA Desensitizer is fully compatible with dental adhesives and luting cements. The bond strength of these materials to the tooth remains on the same level irrespective of whether GLUMA Desensitizer is previously applied on the dentine or not. Some other desensitizing products act only at the tooth surface. This may decrease bond strength to adhesives or cements applied afterwards.1 GLUMA Desensitizer does not interfere with these adhesive materials because they work within the dentinal tubuli.
1 Aranha AC et al.: Microtensile bond strengths of composite to dentine treated with desensitizer products. J Adhes Dent. 2006, 2:85-90.
Why does GLUMA Desensitizer need to be rinsed off?
GLUMA Desensitizer contains glutardialdehyde. This substance is responsible for the effective reduction of dentine hypersensitivity. It is a highly reactive agent able to coagulate proteins. This effect is desired within the dentine tubuli but not on the gingiva and mucosa. We therefore strongly recommend the use of rubber dam. To avoid irritation of oral soft tissues, GLUMA Desensitizer must never touch soft tissue and must be rinsed off with plenty of water by the dentist/dental assistant.
Why does GLUMA Desensitizer need to be air-dried prior to rinsing off?
After application on the hypersensitive tooth area, GLUMA Desensitizer needs to be air-dried. This step increases the desensitizing effect. Afterwards, the desensitizer needs to be rinsed off using plenty of water by the dentist/dental assistant.
Why is rubber dam recommended for the application of GLUMA Desensitizer?
GLUMA Desensitizer contains glutardialdehyde. This agent is very effective in the coagulation of proteins, providing the desired result within the dentine tubuli. However, it also reacts with oral soft tissue when it comes in contact with gingiva or mucosa. This may cause temporary local irritations or necrosis of the soft tissue. To avoid any contact with oral soft tissue, rubber dam needs to be applied.
What happens if GLUMA Desensitizer is accidentally light-cured?
Light-curing does not affect GLUMA Desensitizer. The desensitizer does not contain photocuring ingredients.
Has GLUMA Desensitizer been clinically tested?
GLUMA Desensitizer is one of the most evaluated desensitizers worldwide: at least 34 clinical patient studies were done on the performance of GLUMA Desensitizer and numerous in-vitro investigations. (You will find a list of these studies at the end of this document.)
Does GLUMA Desensitizer reduce dentine hyper sensitivity immediately after application?
Several clinical studies demonstrated a minimisation of the dentine hypersensitivity directly after its application2. Its full effect will occur after some minutes to hours once the reaction of GLUMA Desensitizer with the proteins of the dentine liquor is completed. In some cases, a repeated application of GLUMA Desensitizer may be necessary.
2 Mehta D, et al.: Effi cacy of Dentin Desensitizing Agents: A Randomized Controlled Clinical Trial. J Dent Res 93 (Spec Iss B), 1115, 2014.
How does GLUMA Desensitizer reduce dentine hypersensitivity?
GLUMA Desensitizer contains glutardialdehyde and HEMA ((2-Hydroxyethyl)methacrylate). HEMA enables glutardialdehyde to penetrate up to 200μm into the dentine tubuli3. Inside the tubuli, glutardialdehyde reacts with the proteins present in the dentine liquor. The proteins precipitate and form protein plugs which close the dentine tubuli. This protein coagulation leads to the polymerisation of HEMA4. Because of these coagulated proteins (protein septa), the permeability of the dentine is significantly reduced5 and movements of dentine liquor inside the tubuli or other stimulating effects are lessened. GLUMA Desensitizer functions within the dentine tubuli and therefore do not interfere with adhesive treatments. It does not create a layer on the dentine surface. Other studies have shown further benefits from glutardialdehyde. It inhibits enzymes (MMPs) within the dentine that degrade the hybrid layer of adhesives over time6. Apart from this, glutardialdehyde has also demonstrated its potential for cavity disinfection7. Last but not least, it increases the strength of the dentine and may lead to more durable bonding8.
3 Schüpbach P et al.: Closing of dentinal tubules by Gluma desensitizer. Eur J Oral Sci 1997; 105: 414-421.
4 Qin C et. al.: Spectroscopic investigation of the function of aqueous 2-hydroxyethylmethacrylate/glutaraldehyde solution as a dentin desensitizer. Eur J Oral Sci 114, 2006:354-9.
5 Ishihata H et al.: In vitro dentin permeability after application of Gluma® desensitizer as aqueous solution or aqueous fumed silica dispersion. J Appl Oral Sci 19(2), 2011:147-53.
6 Sabatini C et al.: Inhibition of endogenous human dentin MMPs by Gluma. Dental Mat 30, 2014: 752-8.
7 Felton D et al.: Inhibition of bacterial growth under composite restorations following GLUMA pretreatment. JDR, 68 (3), 1989: 491-5.
8 Bedran-Russo AK et al.: Changes in stiffness of demineralized dentin following application of collagen cross-linkers. J of Biomedical Materials Research Part B: Applied Biomaterials, 86 (B), 2008: 330-4.
How long does the desensitizing effect of GLUMA Desensitizer last?
A recently published clinical study revealed a reduction of dentine hypersensitivity by GLUMA Desensitizer for at least 18 months9. GLUMA Desensitizer was the only tested desensitizing treatment that did not show an increase in pain during the 18 months study observation period.
9 Lopes AO et al.: Evaluation of different treatment protocols for dentine hypersensitivity: an 18-month randomized clinical trial. Lasers Med Sci, 32, 2017:1023-30.
How effi cient is GLUMA Desensitizer compared to other desensitizing methods?
GLUMA Desensitizer has demonstrated their long-term effectiveness of up to 18 months in various clinical studies10. GLUMA Desensitizer is fast and non-invasive. It should only be applied by dentists, though, as it is not intended for use by the patients. It does not interfere with other treatments (e. g. following adhesive treatments) compared to other desensitizing treatments (e.g. desensitizers based on oxalates11, 12). GLUMA Desensitizer is more effective than desensitizers based on an oxalate or calcium phosphate chemistry13, 14, 15.
10 Lopes AO et al.: Evaluation of different treatment protocols for dentine hypersensitivity: an 18-month randomized clinical trial. Lasers Med Sci, 32, 2017:1023-30.
11 Silva SMA et al.: Effect of Oxalate Desensitizer on the Durability of Resin-Bonded Interfaces. Operative Dentistry 35-6, 2010: 610-617.
12 Acar O et al.: The effect of dentin desensitizers and Nd:YAG laser pre-treatment on microtensile bond strength of self-adhesive resin cement to dentin. J Adv Prosthodont 6, 2014: 88-95.
13 Dondi Dall‘ Orologio et al.: In vitro and in vivo evaluation of the effectiveness of three dentin desensitizing treatment regimens. American Journal of Dentistry 27 (3), 2014: 139-144.
14 Mehta D et al.: Randomized controlled clinical trial on the effi cacy of dentin desensitizing agents. Acta Odontologica Scandinavica. 2014; Early Online, 1–6.
15 Vora J et al.: Effects of two topic desensitizing agents and placebo on dentin hypersensitivity. AJD 25,5, 2012:293-8.
How long has GLUMA Desensitizer been on the market?
GLUMA Desensitizer has been launched in 1992. GLUMA We estimate that GLUMA Desensitizer has been applied on teeth about 45 million times and that 34 studies have been carried out on GLUMA Desensitizer. (You will find a list of these studies at the end of this document.)
What is the pH value of GLUMA Desensitizer?
GLUMA Desensitizer has a pH value of 3-4.
Downloads
Clinical Studies & Reports
General Information
Instructions for use
Go to e-IFU Portal
Instructions for Use can be found on the e-IFU portal.
Material Safety Data Sheet
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